Project 1: The Enteric Neurons-Immune Cell Axis
This project focuses on the interactions between enteric neurons and immune cells within the gut. We aim to uncover the mechanisms by which enteric neurons influence immune responses, regulate inflammation, and maintain intestinal homeostasis. Our research explores how specific neuronal circuits communicate with immune cells to defend against pathogens, mediate mucosal defense, and contribute to conditions like inflammatory bowel disease (IBD) and other intestinal disorders.
For instance, we uncovered a novel neuron-immune axis in which enteric serotonergic neurons promote the homing, retention, and activation of plasmacytoid dendritic cells (pDC) via serotonin-HTR7 signaling. This pathway plays a key role in regulating IgA B cell differentiation in the small intestine, contributing to intestinal immune homeostasis and mucosal defense.
Project 2: How enteric neurons senseing infection
This project aims to explore how enteric neurons detect and respond to infections in the gut. We investigate the molecular mechanisms by which enteric neurons sense the presence of pathogens and initiate protective responses.
We have established an infection mouse model along with a protocol for single-cell RNA sequencing (scRNA-seq) of enteric neurons to profile gene expression changes at single-cell resolution during infection. This approach allows us to gain detailed insights into how enteric neurons respond to infections at the molecular level, advancing our understanding of neuron-mediated gut defense mechanisms.
Project 3: How enteric neurons influence social behaviors
In this project, we explore the connection between enteric neurons and social behaviors. Emerging research suggests that the gut-brain axis, particularly enteric neurons, plays a significant role in regulating mood and behavior. We aim to uncover the mechanisms by which enteric neuronal activity influences emotional states like anxiety, happiness, and anger, and how these signals are communicated to the brain. By studying this connection, we hope to provide insights into how gut health affects mental health and social interactions, potentially offering novel approaches to treating mood disorders.
